C. Nicholas Hodge

Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors

Patrick Y. S. Lam, Prabhakar K. Jadhav, Charles J. Eyermann et al. · Science · 1994 · 836 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

Flexibility and function in HIV-1 protease

Linda K. Nicholson, Toshimasa Yamazaki, Dennis A. Torchia et al. · Nature Structural & Molecular Biology · 1995 · 230 citations

Life Sciences, Biochemistry, Molecular Biology +12

Cyclic HIV Protease Inhibitors:  Synthesis, Conformational Analysis, P2/P2‘ Structure−Activity Relationship, and Molecular Recognition of Cyclic Ureas

Patrick Y. S. Lam, Yu Ru, Prabhakar K. Jadhav et al. · Journal of Medicinal Chemistry · 1996 · 170 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

A molecular mechanics/grid method for evaluation of ligand–receptor interactions

Brock A. Luty, Zelda R. Wasserman, Pieter F. W. Stouten et al. · Journal of Computational Chemistry · 1995 · 166 citations

Natural Sciences, Biophysics, Chemistry +13

Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450

C. Nicholas Hodge, Paul E. Aldrich, Lee T. Bacheler et al. · Chemistry & Biology · 1996 · 148 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +16