Yu Ru

Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors

Patrick Y. S. Lam, Prabhakar K. Jadhav, Charles J. Eyermann et al. · Science · 1994 · 834 citations

Combinatorial Chemistry, Bioorganic Chemistry, Nonpeptide Cyclic Ureas +18

Cyclic HIV Protease Inhibitors:  Synthesis, Conformational Analysis, P2/P2‘ Structure−Activity Relationship, and Molecular Recognition of Cyclic Ureas

Patrick Y. S. Lam, Yu Ru, Prabhakar K. Jadhav et al. · Journal of Medicinal Chemistry · 1996 · 170 citations · Full text

Potent and Selective Inhibition of Human Cathepsin K Leads to Inhibition of Bone Resorption In Vivo in a Nonhuman Primate

George B. Stroup, Michael W. Lark, Daniel F. Veber et al. · Journal of Bone and Mineral Research · 2001 · 153 citations

Azepanone-Based Inhibitors of Human and Rat Cathepsin K

Robert W. Marquis, Yu Ru, Steven M. LoCastro et al. · Journal of Medicinal Chemistry · 2001 · 102 citations · Full text

A potent small molecule, nonpeptide inhibitor of cathepsin K (SB 331750) prevents bone matrix resorption in the ovariectomized rat

Michael W. Lark, George B. Stroup, Ian E. James et al. · Bone · 2002 · 78 citations

Sclerostin, Potent Small Molecule, Bone Morphogenic Protein +12