The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet

Alejandro Martín‐Montalvo, Evi M. Mercken, Hector H. Palacios, +12

Cell Reports

AgingAnti-agingImmunologyBiogerontologySrt1720-treated Animals +21

Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys

Thomas W. Geisbert, Lisa E. Hensley, Peter B. Jahrling, +6

The Lancet

Rhesus MonkeysPathogenesisViral PathogenesisImmunologyAntiviral Drug Development +8

SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity

Hongying Yang, Wei Zhang, Heng Pan, +14

PLoS ONE

ImmunologyImmune RegulationInnate ImmunityImmune DysregulationInflammation +14

SRT1720 improves survival and healthspan of obese mice

Robin K. Minor, Joseph A. Baur, Ana P. Gomes, +30

Scientific Reports

APJ acts as a dual receptor in cardiac hypertrophy

Maria Cecilia Scimia, Cecilia Hurtado, Saugata Ray, +16

Nature

Cardiac MuscleCardiomyopathyDual ReceptorSignal TransductionMolecular Physiology +6

<scp>SRT</scp>2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

Evi M. Mercken, Sarah J. Mitchell, Alejandro Martín‐Montalvo, +19

Aging Cell

Mice lacking factor VII develop normally but suffer fatal perinatal bleeding

Elliot D. Rosen, Joyce Chan, Esohe Idusogie, +12

Nature

InflammationFatal Perinatal BleedingKnockout MousePostpartum HemorrhageDevelopmental Biology +7

SIRT1 Activation by Small Molecules

Han Dai, Lauren Kustigian, David P. Carney, +8

Journal of Biological Chemistry

Protein FunctionSignal TransductionCell RegulationBiochemistryMolecular Regulation +13

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

Han Dai, April Case, Thomas V. Riera, +30

Nature Communications

Tissue factor/factor VIIa inhibitors block angiogenesis and tumor growth through a nonhemostatic mechanism.

Todd Hembrough, Glenn M. Swartz, Adonia E. Papathanassiu, +4

PubMed

ImmunologyTumor BiologyThrombosisAngiogenesisCoagulation Inhibitors +17