Concepedia

Thrombin Inhibition

Thrombin Inhibition is a natural anticoagulant mechanism that selectively suppresses the enzymatic activity of thrombin, a key serine protease in the coagulation cascade, thereby preventing excessive fibrin formation and stabilizing hemostatic balance.

4.7K

Publications

249K

Citations

15.9K

Authors

2.7K

Institutions

Publications per year

2017–2026

411

Parents

Publications

4.7K

Selection of single-stranded DNA molecules that bind and inhibit human thrombin

Louis C. Bock, Linda C. Griffin, John Latham et al. · Nature · 1992 · 2.5K citations

, , +13

Reversal of Rivaroxaban and Dabigatran by Prothrombin Complex Concentrate

Elise S. Eerenberg, Pieter W. Kamphuisen, Meertien K. Sijpkens et al. · Circulation · 2011 · 1.4K citations · Full text

, , +17

The Purification and Mechanism of Action of Human Antithrombin-Heparin Cofactor

Robert Rosenberg, Paul S. Damus · Journal of Biological Chemistry · 1973 · 1.4K citations · Full text

, , +17

Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors.

Jeffrey I. Weitz, Monika Hudoba, David Massel et al. · Journal of Clinical Investigation · 1990 · 1.1K citations · Full text

, , +16

Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide.

Chantal M. Boulanger, Thomas F. Lüscher · Journal of Clinical Investigation · 1990 · 1.1K citations · Full text

, , +10

1–5 of 4.7K

Authors

15.9K

  1. JW
    John W. Fenton

    New York State Department of Health, United States

    53 publications · 3.7K citations

    34

    h-index

  2. JI
    Jeffrey I. Weitz

    McMaster University, Canada

    48 publications · 3.9K citations

    28

    h-index

  3. ST
    Steven T. Olson

    University of Illinois Chicago, United States

    33 publications · 2.7K citations

    27

    h-index

  4. CT
    Charles T. Esmon

    Oklahoma Medical Research Foundation, United States

    29 publications · 3.5K citations

    26

    h-index

  5. SR
    Stuart R. Stone

    Friedrich Miescher Institute, Switzerland

    33 publications · 2.7K citations

    26

    h-index

1–5 of 15.9K

Institutions

2.7K

  1. Washington University in St. Louis

    St Louis, United States

    43 h-index

    234 publications

    19.9K citations

  2. McMaster University

    Hamilton, Canada

    37 h-index

    443 publications

    24.2K citations

  3. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    35 h-index

    235 publications

    11.6K citations

  4. AstraZeneca (Sweden)

    Södertälje, Sweden

    34 h-index

    216 publications

    16K citations

  5. Inserm

    Paris, France

    33 h-index

    368 publications

    19.3K citations

  6. United States Military Academy

    West Point, United States

    32 h-index

    552 publications

    28.5K citations

  7. University of Illinois Chicago

    Chicago, United States

    32 h-index

    167 publications

    10.6K citations

  8. Harvard University

    Cambridge, United States

    31 h-index

    193 publications

    15.2K citations

1–8 of 2.7K

Venues

  1. Journal of Biological Chemistry

    JBC · 388 publications · 34.8K citations

    97

    h-index

  2. Thrombosis and Haemostasis

    373 publications · 16.1K citations

    62

    h-index

  3. Biochemistry

    127 publications · 8.3K citations

    52

    h-index

  4. Thrombosis Research

    283 publications · 9.9K citations

    50

    h-index

  5. Blood

    118 publications · 7.6K citations

    49

    h-index

1–5