An Orally Available Small-Molecule Inhibitor of c-Met, PF-2341066, Exhibits Cytoreductive Antitumor Efficacy through Antiproliferative and Antiangiogenic Mechanisms

Helen Y. Zou, Qiuhua Li, Joseph H. Lee, +12

Cancer Research

Tumor BiologyC-met KinaseChemoprevention StrategyNovel TherapyMedicine +13

A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo.

James G. Christensen, Randall Schreck, Jon Burrows, +13

PubMed

Cancer BiologyTumor BiologyC-met KinaseSignaling PathwayReceptor Tyrosine Kinase +18

Safety and preliminary clinical activity of repotrectinib in patients with advanced <i>ROS1</i> fusion-positive non-small cell lung cancer (TRIDENT-1 study).

Byoung Chul Cho, Alexander Drilon, Robert C. Doebele, +12

Journal of Clinical Oncology

Trident-1 StudyPathologyTumor BiologyOncologyReceptor Tyrosine Kinase +15

Sensitivity of Selected Human Tumor Models to PF-04217903, a Novel Selective c-Met Kinase Inhibitor

Helen Y. Zou, Qiuhua Li, Joseph H. Lee, +13

Molecular Cancer Therapeutics

Tumor BiologyC-met PathwayOncologyChemoprevention StrategyMedicine +12

Inhibitors targeting hepatocyte growth factor receptor and their potential therapeutic applications

Jingrong Jean Cui

Expert Opinion on Therapeutic Patents

Potential Therapeutic ApplicationsTumor BiologyFibroblast Growth FactorHepatotoxicityAnti-cancer Agent +18

Z-Ajoene Induces Apoptosis of HL-60 Cells: Involvement of Bcl-2 Cleavage

Min Li, Ji‐Mei Min, Jingrong Jean Cui, +6

Nutrition and Cancer

Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain

Sharan K. Bagal, Mark D. Andrews, Bruce M. Bechle, +27

Journal of Medicinal Chemistry

Drug TargetPain MedicineMolecular PainPharmacotherapyPharmaceutical Chemistry +17

Novel pyrrolyllactone and pyrrolyllactam indolinones as potent cyclin-Dependent kinase 2 inhibitors

Xiaoyuan Li, Ping Huang, Jingrong Jean Cui, +2

Bioorganic & Medicinal Chemistry Letters

Novel PyrrolyllactoneMedicinal ChemistryBiochemistryMedicineNatural Sciences +10

Non-covalent thrombin inhibitors featuring p3-heterocycles with P1-monocyclic arginine surrogates

John Reiner, Daniel V. Siev, Gian‐Luca Araldi, +12

Bioorganic & Medicinal Chemistry Letters

Non-covalent thrombin inhibitors featuring P3-Heterocycles with P1-Bicyclic arginine surrogates

Jingrong Jean Cui, Gian‐Luca Araldi, John Reiner, +12

Bioorganic & Medicinal Chemistry Letters

ThrombosisMedicinal ChemistryMedicineNon-covalent Thrombin InhibitorsPharmacotherapy +5