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Active site inhibitors of HCV NS5B polymerase. The development and pharmacophore of 2-thienyl-5,6-dihydroxypyrimidine-4-carboxylic acid

Ian Stansfield, Salvatore Avolio, Stefania Colarusso, Nadia Gennari, Frank Narjes, Barbara Pacini, Simona Ponzi, Steven J. Harper

Bioorganic & Medicinal Chemistry Letters · 2004 · 41 citations · 9 references

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References

9

Peginterferon Alfa-2a in Patients with Chronic Hepatitis C

Stefan Zeuzem, S.V. Feinman, J. Rasenack et al. · New England Journal of Medicine · 2000 · 1.2K citations · Full text

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Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site.

Patricia C Weber, Charles A. Lesburg, Michael Cable et al. · Nature Structural Biology · 1999 · 732 citations

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Identification and properties of the RNA‐dependent RNA polymerase of hepatitis C virus.

Sven‐Erik Behrens, Licia Tomei, Raffaele De Francesco · The EMBO Journal · 1996 · 685 citations · Full text

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Discovery of α,γ-Diketo Acids as Potent Selective and Reversible Inhibitors of Hepatitis C Virus NS5b RNA-Dependent RNA Polymerase

Vincenzo Summa, Alessia Petrocchi, Paola Pace et al. · Journal of Medicinal Chemistry · 2003 · 122 citations · Full text

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Identification of <i>N,N</i>-Disubstituted Phenylalanines as a Novel Class of Inhibitors of Hepatitis C NS5B Polymerase

Laval Chan, T. Jagadeeswar Reddy, Mélanie Proulx et al. · Journal of Medicinal Chemistry · 2003 · 68 citations · Full text

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