A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease

Frank Narjes, Konrad F. Koehler, Uwe Koch, +7

Bioorganic & Medicinal Chemistry Letters

P1 Cysteine MimeticBiochemistryNatural SciencesAntiviral Drug DevelopmentMolecular Biology +6

Inhibition of the Hepatitis C Virus NS3/4A Protease

Stefania Di Marco, Menico Rizzi, Cinzia Volpari, +6

Journal of Biological Chemistry

2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as Inhibitors of the Hepatitis C Virus NS5B Polymerase:  Discovery, SAR, Modeling, and Mutagenesis

Uwe Koch, Barbara Attenni, Savina Malancona, +13

Journal of Medicinal Chemistry

α-Ketoacids Are Potent Slow Binding Inhibitors of the Hepatitis C Virus NS3 Protease

Frank Narjes, Mirko Brunetti, Stefania Colarusso, +7

Biochemistry

Viral ReplicationProtein AssemblyHepatitis C VirusMolecular BiologyAntiviral Drug +16

Discovery of (7<i>R</i>)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6<i>H</i>-indolo[1,2-<i>e</i>][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a Potent and Orally Bioavailable Finger-Loop Inhibitor of the Hepatitis C Virus NS5B Polymerase

Frank Narjes, Benedetta Crescenzi, Marco Ferrara, +21

Journal of Medicinal Chemistry

Evolution, synthesis and SAR of tripeptide α-ketoacid Inhibitors of the hepatitis C virus NS3/NS4A serine protease

Stefania Colarusso, Benjamin Gerlach, Uwe Koch, +5

Bioorganic & Medicinal Chemistry Letters

Tripeptide α-Ketoacid InhibitorsBiochemistryNatural SciencesMedicineAntiviral Drug Development +7

Active site inhibitors of HCV NS5B polymerase. The development and pharmacophore of 2-thienyl-5,6-dihydroxypyrimidine-4-carboxylic acid

Ian Stansfield, Salvatore Avolio, Stefania Colarusso, +5

Bioorganic & Medicinal Chemistry Letters

Hcv Ns5b PolymeraseActive Site InhibitorsBiochemistryMedicineAntiviral Drug Development +8

Phenethyl Amides as Novel Noncovalent Inhibitors of Hepatitis C Virus NS3/4A Protease:  Discovery, Initial SAR, and Molecular Modeling

Stefania Colarusso, Uwe Koch, Benjamin Gerlach, +5

Journal of Medicinal Chemistry

Antiviral DrugChemical BiologyMedicinal ChemistryPhenethyl Amide GroupAntiviral Drug Development +14

Katritzky Salts for the Synthesis of Unnatural Amino Acids and Late‐Stage Functionalization of Peptides

Ali Munaim Yousif, Stefania Colarusso, Elisabetta Bianchi

European Journal of Organic Chemistry

Bioorganic ChemistryPeptide EngineeringPeptide SciencePeptide TherapeuticsPeptide Drug Discovery +20

Optimization of Thienopyrrole‐Based Finger‐Loop Inhibitors of the Hepatitis C Virus NS5B Polymerase

José Ignacio Martı́n Hernando, Jesus M. Ontoria, Savina Malancona, +13

ChemMedChem

Viral Polymerase StructureHepatitis C VirusMolecular BiologyPharmacotherapyAntiviral Drug +14