2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as Inhibitors of the Hepatitis C Virus NS5B Polymerase:  Discovery, SAR, Modeling, and Mutagenesis

Uwe Koch, Barbara Attenni, Savina Malancona, +13

Journal of Medicinal Chemistry

A new route to 2-alkenyl-1,3-dicarbonyl compounds, intermediates in the synthesis of dihydrofurans

Roberto Antonioletti, Paolo Bovicelli, Savina Malancona

Tetrahedron

EngineeringAlkene MetathesisOrganic ChemistryChemistryHeterocycle Chemistry +5

Identification and Biological Evaluation of a Series of 1<i>H</i>-Benzo[<i>de</i>]isoquinoline-1,3(2<i>H</i>)-diones as Hepatitis C Virus NS5B Polymerase Inhibitors

Jesus M. Ontoria, Edwin H. Rydberg, Stefania Di Marco, +14

Journal of Medicinal Chemistry

Identification of thieno[3,2-b]pyrroles as allosteric inhibitors of hepatitis C virus NS5B polymerase

Jesus M. Ontoria, José Ignacio Martı́n Hernando, Savina Malancona, +10

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineAntiviral Drug DevelopmentAntiviral TherapyHepatitis +5

Discovery of a Selective Series of Inhibitors of <i>Plasmodium falciparum</i> HDACs

Jesus M. Ontoria, Giacomo Paonessa, Simona Ponzi, +19

ACS Medicinal Chemistry Letters

Antiparasitic AgentMalariaPharmacotherapyNew SeriesChemical Biology +15

Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo- propyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydro-imidazo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, Part 2

Olaf Kinzel, Anna B. Alfieri, Sergio Altamura, +18

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ChemistryPart 2MedicinePathology +8

Improved Selective Class I HDAC and Novel Selective HDAC3 Inhibitors: Beyond Hydroxamic Acids and Benzamides

Alberto Bresciani, Jesus M. Ontoria, Ilaria Biancofiore, +14

ACS Medicinal Chemistry Letters

Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: Structure-based design and synthesis of new templates

Savina Malancona, Monica Donghi, Marco Ferrara, +7

Bioorganic & Medicinal Chemistry

Antiviral CompoundBiochemistryNatural SciencesAntiviral Drug DevelopmentAntiviral Therapy +9

Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydroimid azo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, Part 1

Savina Malancona, Sergio Altamura, Gessica Filocamo, +6

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPart 1Pharmaceutical ScienceMedicinePathology +8

Optimization of Thienopyrrole‐Based Finger‐Loop Inhibitors of the Hepatitis C Virus NS5B Polymerase

José Ignacio Martı́n Hernando, Jesus M. Ontoria, Savina Malancona, +13

ChemMedChem

Viral Polymerase StructureHepatitis C VirusMolecular BiologyPharmacotherapyAntiviral Drug +14