Laval Chan

Crystal Structures of the RNA-dependent RNA Polymerase Genotype 2a of Hepatitis C Virus Reveal Two Conformations and Suggest Mechanisms of Inhibition by Non-nucleoside Inhibitors

B.K. Biswal, M.M. Cherney, Meitian Wang et al. · Journal of Biological Chemistry · 2005 · 194 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Non-nucleoside Analogue Inhibitors Bind to an Allosteric Site on HCV NS5B Polymerase

Meitian Wang, Kenneth Ng, M.M. Cherney et al. · Journal of Biological Chemistry · 2003 · 192 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +16

Discovery of Thiophene‐2‐carboxylic Acids as Potent Inhibitors of HCV NS5B Polymerase and HCV Subgenomic RNA Replication. Part 2. Tertiary Amides.

Laval Chan, et al. et al. · ChemInform · 2004 · 103 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides

Laval Chan, Sanjoy Das, T. Jagadeeswar Reddy et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 76 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Non-nucleoside Inhibitors Binding to Hepatitis C Virus NS5B Polymerase Reveal a Novel Mechanism of Inhibition

B.K. Biswal, Meitian Wang, M.M. Cherney et al. · Journal of Molecular Biology · 2006 · 75 citations

Life Sciences, Medicinal Chemistry, Molecular Biology +13