Imidazopyrimidines, potent inhibitors of p38 MAP kinase

Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function.

A M Badger, Jeremy N. Bradbeer, Bartholomew J. Votta et al. · Journal of Pharmacology and Experimental Therapeutics · 1996 · 499 citations

Medicine, Immunology, Pharmacology +17

Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase

Timothy F. Gallagher, George Seibel, Shouki Kassis et al. · Bioorganic & Medicinal Chemistry · 1997 · 218 citations

Life Sciences, Immunology, Molecular Biology +14

Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase

Nigel J. Liverton, John W. Butcher, Christopher F. Claiborne et al. · Journal of Medicinal Chemistry · 1999 · 196 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

RWJ 67657, a Potent, Orally Active Inhibitor of p38 Mitogen-Activated Protein Kinase

Scott Wadsworth, Druie Cavender, Scott A. Beers et al. · Journal of Pharmacology and Experimental Therapeutics · 1999 · 158 citations

Medicine, Immunology, Pharmacology +17

Pyrimidinylimidazole inhibitors of CSBP/P38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes

Jerry L. Adams, Jeffrey C. Boehm, Shouki Kassis et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 113 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16