John J. Siekierka

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

John J. Siekierka, Shirley H.Y. Hung, Martin Poe et al. · Nature · 1989 · 1K citations

Life Sciences, Biochemistry, Pharmacology +9

The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes.

Michael J. Tocci, D A Matkovich, Kathy Collier et al. · The Journal of Immunology · 1989 · 670 citations

Life Sciences, Immunology, Pharmacology +16

The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin.

Francis J. Dumont, Mary Jo Staruch, Sam L. Koprak et al. · The Journal of Experimental Medicine · 1992 · 253 citations · Full text

Medicine, Immunology, Pharmacology +17

Imidazopyrimidines, potent inhibitors of p38 MAP kinase

Kenneth C. Rupert, James R. Henry, John H. Dodd et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 252 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9

Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?

N H Sigal, Francis J. Dumont, P. L. DURETTE et al. · The Journal of Experimental Medicine · 1991 · 249 citations · Full text

Medicine, Immunology, Pharmacology +13