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Pyrimidinylimidazole inhibitors of CSBP/P38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes

Jerry L. Adams, Jeffrey C. Boehm, Shouki Kassis, Peter D. Gorycki, Edward F. Webb, Ralph Hall, Margaret E. Sorenson, John C. Lee, Andrew D. Ayrton, Don E. Griswold,

Bioorganic & Medicinal Chemistry Letters · 1998 · 113 citations · 11 references

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A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

John C. Lee, Jeffrey T. Laydon, Peter McDonnell et al. · Nature · 1994 · 3.3K citations

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SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

Ana Cuenda, J.B. Rouse, Yair N. Doza et al. · FEBS Letters · 1995 · 2.1K citations

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A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

Liang Tong, Susan Pav, Della White et al. · Nature Structural Biology · 1997 · 386 citations

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Chemistry of sulfonylmethyl isocyanides. 12. Base-induced cycloaddition of sulfonylmethyl isocyanides to carbon,nitrogen double bonds. Synthesis of 1,5-disubstituted and 1,4,5-trisubstituted imidazoles from aldimines and imidoyl chlorides

A. M. VAN LEUSEN, Jurjen Wildeman, O. H. OLDENZIEL · The Journal of Organic Chemistry · 1977 · 312 citations

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The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase

Keith P. Wilson, Patricia G. McCaffrey, Kathy Hsiao et al. · Chemistry & Biology · 1997 · 275 citations · Full text

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