Pharmacologic Inhibition of MNKs in Acute Myeloid Leukemia

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Proposed Revised Criteria for the Classification of Acute Myeloid Leukemia

John M. Bennett · Annals of Internal Medicine · 1985 · 3K citations

Medicine, Hematology, Oncology +8

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

Anne‐Claude Gingras, Steven P. Gygi, Brian Raught et al. · Genes & Development · 1999 · 1.3K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

Patrick E. Burnett, Roxanne K. Barrow, Noam A. Cohen et al. · Proceedings of the National Academy of Sciences · 1998 · 1.1K citations

Life Sciences, Cell Biology, Molecular Biology +14

Mitogen‐activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

Andrew J. Waskiewicz · The EMBO Journal · 1997 · 945 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +7