Matthew J. Sykes

Discovery of 5‐(2‐(Phenylamino)pyrimidin‐4‐yl)thiazol‐2(3<i>H</i>)‐one Derivatives as Potent Mnk2 Inhibitors: Synthesis, SAR Analysis and Biological Evaluation

Sarah Diab, Theodosia Teo, Malika Kumarasiri et al. · ChemMedChem · 2014 · 81 citations

Medicine, Medicinal Chemistry, Pharmacology +10

DNA Binding of an Organic dppz-Based Intercalator

Tim Phillips, Ihtshamul Haq, Anthony J. H. M. Meijer et al. · Biochemistry · 2004 · 73 citations

Natural Sciences, Chemistry, Molecular Biology +12

Prediction of Metabolism by Cytochrome P450 2C9: Alignment and Docking Studies of a Validated Database of Substrates

Matthew J. Sykes, Ross A. McKinnon, John O. Miners · Journal of Medicinal Chemistry · 2008 · 71 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

The Gaussian Generalized Born model: application to small molecules

Jennifer Grant, Barry T. Pickup, Matthew J. Sykes et al. · Physical Chemistry Chemical Physics · 2007 · 65 citations

Natural Sciences, Chemistry, Physics +12

Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia cells

Theodosia Teo, Mingfeng Yu, Yuchao Yang et al. · Cancer Letters · 2014 · 43 citations

Medicine, Oncology, Pharmacology +14