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Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

Theonie Anastassiadis, Sean Deacon, Karthik Devarajan, Haiching Ma, Jeffrey R. Peterson

Nature Biotechnology · 2011 · 926 citations · 25 references

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References

25

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

, , +14

Specificity and mechanism of action of some commonly used protein kinase inhibitors

Stephen Davies, Helen Reddy, Matilde Caivano et al. · Biochemical Journal · 2000 · 4.1K citations · Full text

, , +13

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

John C. Lee, Jeffrey T. Laydon, Peter McDonnell et al. · Nature · 1994 · 3.3K citations

, , +14

Specificity and mechanism of action of some commonly used protein kinase inhibitors

Stephen Davies, Helen Reddy, Matilde Caivano et al. · Biochemical Journal · 2000 · 3.1K citations

, , +13

The selectivity of protein kinase inhibitors: a further update

Jenny Bain, Lorna Plater, Matt Elliott et al. · Biochemical Journal · 2007 · 2.5K citations · Full text

, , +14