Dissecting the Mechanisms of Tissue Transglutaminase-induced Cross-linking of α-Synuclein

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

Mihael H. Polymeropoulos, Christian Lavedan, Elisabeth Leroy et al. · Science · 1997 · 8.2K citations

α-Synuclein is phosphorylated in synucleinopathy lesions

Hideo Fujiwara, Masato Hasegawa, Naoshi Dohmae et al. · Nature Cell Biology · 2002 · 2.1K citations

Neurodegenerative Diseases, Molecular Neuroscience, Molecular Biology +8

Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy

Kelly A. Conway, Seung‐Jae Lee, Jean‐Christophe Rochet et al. · Proceedings of the National Academy of Sciences · 2000 · 1.5K citations

Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease

Kelly A. Conway, James D. Harper, Peter T. Lansbury · Nature Medicine · 1998 · 1.5K citations · Full text

Neurodegenerative Diseases, Vitro Fibril Formation, Molecular Biology +6

Release of long-range tertiary interactions potentiates aggregation of natively unstructured α-synuclein

Carlos W. Bertoncini, Young‐Sang Jung, Claudio O. Fernández et al. · Proceedings of the National Academy of Sciences · 2005 · 778 citations · Full text