Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

Vuk Stambolic, Akira Suzuki, José Luís de la Pompa et al. · Cell · 1998 · 2.5K citations · Full text

Tumor Biology, Signal Transduction, Signaling Pathway +12

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

Thomas Franke, Sung‐Il Yang, Tung O. Chan et al. · Cell · 1995 · 2K citations · Full text

Akt Proto-oncogene, Signal Transduction, Signaling Pathway +11

Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3

Hitoshi Niwa, Tom Burdon, Ian Chambers et al. · Genes & Development · 1998 · 1.5K citations · Full text

Regenerative Medicine, Lineage Plasticity, Induced Pluripotent Stem Cell +14

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

Masayuki Otsu, I. Hiles, Ivan Gout et al. · Cell · 1991 · 784 citations

Kd Proteins, Signal Transduction, Signaling Pathway +13

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3

Rachel Chapman, Paula C. Lourenco, Elizabeth Tonner et al. · Genes & Development · 1999 · 479 citations · Full text