The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

Ivaylo I. Ivanov, Brent S. McKenzie, Liang Zhou, +5

Cell

InflammationCytokineLymphocyte DevelopmentImmune RegulationImmunology +7

Development, cytokine profile and function of human interleukin 17–producing helper T cells

Nicholas J. Wilson, Katia Boniface, Jason R. Chan, +13

Nature Immunology

InflammationCytokineImmune Cell DevelopmentImmunologyT Cell Immunity +8

Phenotypic and functional features of human Th17 cells

Francesco Annunziato, Lorenzo Cosmi, Veronica Santarlasci, +13

The Journal of Experimental Medicine

Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells

Eva V. Acosta Rodríguez, Giorgio Napolitani, Antonio Lanzavecchia, +1

Nature Immunology

InflammationCytokineLymphocyte DevelopmentImmune Cell DevelopmentImmunology +9

Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells

Eva V. Acosta Rodríguez, Laura Rivino, Jens Geginat, +5

Nature Immunology

Adaptive Immune SystemImmune Cell DevelopmentImmunologyImmunodominanceAntigenic Specificity +10

TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology

Mandy J. McGeachy, Kristian Sass Bak‐Jensen, Yi Chen, +4

Nature Immunology

InflammationCytokineT CellsImmunologyT Cell Immunity +6

Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation

Arian Laurence, Cristina M. Tato, Todd S. Davidson, +9

Immunity

InflammationCytokineAutoimmune DiseaseImmune Cell DevelopmentInterleukin-2 Signaling +8

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

Kamran Ghoreschi, Arian Laurence, Xiang‐Ping Yang, +18

Nature

InflammationTgf-β SignallingImmunologyPathologyAutoimmunity +9

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

Nicolas Manel, Derya Unutmaz, Dan R. Littman

Nature Immunology

Human Th-17 CellsSignal TransductionHuman GrowthImmune Cell DevelopmentLymphocyte Development +6

Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling

Yeonseok Chung, Seon Hee Chang, Gustavo Martínez, +8

Immunity

InflammationCytokineAutoimmune DiseaseImmune Cell DevelopmentCritical Regulation +8