In Vitro Metabolism Studies of Nomifensine Monooxygenation Pathways: Metabolite Identification, Reaction Phenotyping, and Bioactivation Mechanism

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

Tsutomu Shimada, Hiroshi Yamazaki, Mayumi Mimura et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 2.8K citations

Medicine, Biochemistry, Pharmacology +15

Validation of Bupropion Hydroxylation as a Selective Marker of Human Cytochrome P450 2B6 Catalytic Activity

Stephanie Faucette, Roy L. Hawke, Edward L. LeCluyse et al. · Drug Metabolism and Disposition · 2000 · 356 citations

Medicine, Biochemistry, Pharmacology +17

Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by Human CYP3A4

Kenneth E. Thummel, Caroline A. Lee, Kent L. Kunze et al. · Biochemical Pharmacology · 1993 · 294 citations

Medicine, Pharmacology, Drug Metabolism +7

Further Characterization of the Expression in Liver and Catalytic Activity of CYP2B6

Sean Ekins, Mark VandenBranden, B J Ring et al. · Journal of Pharmacology and Experimental Therapeutics · 1998 · 179 citations

Medicine, Biochemistry, Pharmacology +16

The Role of Metabolite-Specific Antibodies in Nomifensine-Dependent Immune Hemolytic Anemia

Abdulgabar Salama, C. Mueller‐Eckhardt · New England Journal of Medicine · 1985 · 113 citations

Medicine, Immunology, Pharmacology +10