Doug Burdette

Interindividual and Regional Variability in Drug Transporter Abundance at the Human Blood–Brain Barrier Measured by Quantitative Targeted Proteomics

Sarah Billington, Laurent Salphati, Cornelis E. C. A. Hop et al. · Clinical Pharmacology & Therapeutics · 2019 · 76 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis

Brian T. Hopkins, Eris Bame, Bekim Bajrami et al. · Journal of Medicinal Chemistry · 2021 · 42 citations · Full text

Pharmacy, Medicinal Chemistry, Neurology +14

Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders

Simone Bonazzi, Carleton P. Goold, Audrey Gray et al. · Journal of Medicinal Chemistry · 2020 · 32 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Elucidation of a Novel Bioactivation Pathway of a 3,4-Unsubstituted Isoxazole in Human Liver Microsomes: Formation of a Glutathione Adduct of a Cyanoacrolein Derivative after Isoxazole Ring Opening

Jian Yu, James J. Folmer, Valerie Hoesch et al. · Drug Metabolism and Disposition · 2010 · 24 citations

Medicine, Biochemistry, Pharmacology +17

In Vitro Metabolism Studies of Nomifensine Monooxygenation Pathways: Metabolite Identification, Reaction Phenotyping, and Bioactivation Mechanism

Jian Yu, Dean G. Brown, Doug Burdette · Drug Metabolism and Disposition · 2010 · 24 citations

Medicine, Biochemistry, Pharmacology +15