Valerie Hoesch

Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5)

Jeffrey Varnes, Andrew P. Marcus, Russell C. Mauger et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 33 citations · Full text

Biochemistry, G Protein-coupled Receptor, Medicine +6

4-Aryl piperazine and piperidine amides as novel mGluR5 positive allosteric modulators

Hui Xiong, Todd A. Brugel, Michael Balestra et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 27 citations · Full text

Combinatorial Chemistry, Molecular Pharmacology, Diversity Oriented Synthesis +9

Azepines and Piperidines with Dual Norepinephrine Dopamine Uptake Inhibition and Antidepressant Activity

Dean G. Brown, Peter R Bernstein, Ye Wu et al. · ACS Medicinal Chemistry Letters · 2012 · 27 citations · Full text

Psychotropic Medication, Psychopharmacology, Antidepressant Activity +16

Elucidation of a Novel Bioactivation Pathway of a 3,4-Unsubstituted Isoxazole in Human Liver Microsomes: Formation of a Glutathione Adduct of a Cyanoacrolein Derivative after Isoxazole Ring Opening

Jian Yu, James J. Folmer, Valerie Hoesch et al. · Drug Metabolism and Disposition · 2010 · 23 citations

Design and structure–activity relationships of novel inhibitors of human rhinovirus 3C protease

Sameer Kawatkar, Moriah M. Gagnon, Valerie Hoesch et al. · Bioorganic & Medicinal Chemistry Letters · 2016 · 20 citations

Virus Structure, Medicine, Immunology +10