Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the London mutant of human APP in neurons

Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

Takeshi Iwatsubo, Asano Odaka, Nobuhiro Suzuki et al. · Neuron · 1994 · 1.8K citations

Life Sciences, Neuroscience, Pathology +16

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

Peter Seubert, Carmen Vigo‐Pelfrey, Fred Esch et al. · Nature · 1992 · 1.7K citations

Life Sciences, Biochemistry, Neuroscience +13

Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

Efrat Levy, M. D. Carman, Ivan Fernandez‐Madrid et al. · Science · 1990 · 1.4K citations

Life Sciences, Genetics, Molecular Genetics +17

Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

Alex E. Roher, Jonathan D. Lowenson, Steven Clarke et al. · Journal of Biological Chemistry · 1993 · 799 citations · Full text

Life Sciences, Neurology, Neuroscience +17

beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease.

Alex E. Roher, Jonathan D. Lowenson, Steven Clarke et al. · Proceedings of the National Academy of Sciences · 1993 · 742 citations

Life Sciences, Neurobiology, Neuroscience +17