Fred Van Leuven

Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain

Dieder Moechars, Ilse Dewachter, Kristin Lorent et al. · Journal of Biological Chemistry · 1999 · 666 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

Rolf Postina, Anja Schroeder, Ilse Dewachter et al. · Journal of Clinical Investigation · 2004 · 621 citations

Life Sciences, Neurobiology, Neuroscience +17

Acute treatment with the PPARγ agonist pioglitazone and ibuprofen reduces glial inflammation and Aβ1–42 levels in APPV717I transgenic mice

Michael T. Heneka, Magdalena Sastre, Lucia Dumitrescu‐Ozimek et al. · Brain · 2005 · 559 citations · Full text

Medicine, Neuroscience, Pharmacology +17

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

An Herreman, Dieter Hartmann, Wim Annaert et al. · Proceedings of the National Academy of Sciences · 1999 · 521 citations

Life Sciences, Genetics, Molecular Genetics +10

Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis

Patricia Rada, Ana I. Rojo, Nathalie Evrard‐Todeschi et al. · Molecular and Cellular Biology · 2012 · 473 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16