FK-506 and cyclosporin A inhibit highly similar signal transduction pathways in human T lymphocytes

An alternative pathway of T-cell activation: A functional role for the 50 kd T11 sheep erythrocyte receptor protein

Stefan Meuer, Rebecca E. Hussey, Marina Fabbi et al. · Cell · 1984 · 1.1K citations

Signal Transduction, Lymphocyte Development, T-regulatory Cell +9

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

John J. Siekierka, Shirley H.Y. Hung, Martin Poe et al. · Nature · 1989 · 1K citations

Inflammation, Protein Function, Signal Transduction +12

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

Tullia Lindstein, Carl H. June, Jeffrey A. Ledbetter et al. · Science · 1989 · 891 citations

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.

John B. Imboden, John D. Stobo · The Journal of Experimental Medicine · 1985 · 732 citations

T-regulatory Cell, Immunology, Ca2+ Ionophore +16

The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes.

Michael J. Tocci, D A Matkovich, Kathy Collier et al. · The Journal of Immunology · 1989 · 669 citations