C. Shirley Lin

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

John J. Siekierka, Shirley H.Y. Hung, Martin Poe et al. · Nature · 1989 · 1K citations

Inflammation, Protein Function, Signal Transduction +12

The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin.

Francis J. Dumont, Mary Jo Staruch, Sam L. Koprak et al. · The Journal of Experimental Medicine · 1992 · 253 citations · Full text

Immunotoxicology, Toxic Effects, Immunology +19

Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation.

C. Shirley Lin, Robert C. Boltz, Joseph T. Blake et al. · The Journal of Experimental Medicine · 1993 · 238 citations · Full text

T-regulatory Cell, Immunology, Immune Regulation +22

Alternative extracellular and cytoplasmic domains of the integrin alpha 7 subunit are differentially expressed during development.

Barry L. Ziober, Mai Vu, Nahid Waleh et al. · Journal of Biological Chemistry · 1993 · 150 citations · Full text

Cardiac Muscle, Adult Skeletal Muscle, Cytoskeleton +20

FK-506 and cyclosporin A inhibit highly similar signal transduction pathways in human T lymphocytes

C. Shirley Lin, Robert C. Boltz, John J. Siekierka et al. · Cellular Immunology · 1991 · 104 citations

Signal Transduction, Autoimmune Disease, T-regulatory Cell +13