Concepedia

Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors

Chamakura V.N.S. Varaprasad, Dinesh A. Barawkar, Hassan El Abdellaoui, Subrata Chakravarty, Matthew Allan, Huanming Chen, Weijian Zhang, Jim Zhen Wu, Robert C. Tam, Robert Hamatake,

Bioorganic & Medicinal Chemistry Letters · 2006 · 35 citations · 29 references

DOIFull text

Open access

Concepts

References

29

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

Margaret Favata, Kurumi Y. Horiuchi, Elizabeth J. Manos et al. · Journal of Biological Chemistry · 1998 · 3K citations · Full text

, , +13

Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

Rika Hoshino, Yuji Chatani, Takao Yamori et al. · Oncogene · 1999 · 693 citations

, , +16

Hyperexpression of mitogen-activated protein kinase in human breast cancer.

Vivek Sivaraman, He Wang, Gerard J. Nuovo et al. · Journal of Clinical Investigation · 1997 · 452 citations · Full text

, , +17

MEK inhibitors: The chemistry and biological activity of U0126, its analogs, and cyclization products

John V. Duncia, Joseph B. Santella, C. Anne Higley et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 406 citations · Full text

, , +11

Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

Changying Zheng, Kun‐Liang Guan · The EMBO Journal · 1994 · 398 citations · Full text

, , +10