Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

Rika Hoshino, Yuji Chatani, Takao Yamori, +8

Oncogene

Human TumorsTumor BiologySignal TransductionSignaling PathwayCell Regulation +10

Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinoma.

Hiroya Oka, Yuji Chatani, Rika Hoshino, +7

PubMed

Renal PathologyMapk CascadeCancer BiologyTumor BiologySignaling Pathway +16

Tumor necrosis factor stimulates the synthesis and secretion of biologically active nerve growth factor in non-neuronal cells.

Akira Hattori, Eriko Tanaka, K. Murase, +5

Journal of Biological Chemistry

ImmunologyPeripheral NerveCell GrowthPeripheral NervesCellular Physiology +17

Biphasic activation of two mitogen-activated protein kinases during the cell cycle in mammalian cells.

Hiroyuki Tamemoto, Takashi Kadowaki, Kazuyuki Tobe, +7

Journal of Biological Chemistry

Mitogen-activated Protein KinasesImmunologyPathologyCell ProliferationCell Cycle +18

Activation of the 41/43 kDa mitogen-activated protein kinase signaling pathway is required for hepatocyte growth factor-induced cell scattering

Susumu Tanimura, Yuji Chatani, Rika Hoshino, +5

Oncogene

Signal TransductionSignaling PathwayCell RegulationReceptor Tyrosine KinaseLiver Physiology +7

Cell type-specific modulation of cell growth by transforming growth factor beta 1 does not correlate with mitogen-activated protein kinase activation.

Yuji Chatani, Susumu Tanimura, Naomi Miyoshi, +3

PubMed

Tyrosine Phosphorylation and Activation of Mitogen-Activated Protein Kinases by Thrombin in Human Platelets: Possible Involvement in Late Arachidonic Acid Release

Shigeru Nakashima, Yuji Chatani, Mitsuhiro Nakamura, +3

Biochemical and Biophysical Research Communications

ThrombopoiesisThrombosisTyrosine PhosphorylationHuman PlateletsSignal Transduction +13

Mitogen-induced tyrosine-phosphorylated 41- and 43-kDa proteins are family members of extracellular signal-regulated kinases/microtubule-associated protein 2 kinases.

Yuji Chatani, Kazuyuki Tobe, Akira Hattori, +6

Journal of Biological Chemistry

Protein SecretionFamily MembersMolecular RegulationImmunologyMolecular Biology +21

Mitogenic signaling pathways of growth factors can be distinguished by the involvement of pertussis toxin-sensitive guanosine triphosphate-binding protein and of protein kinase C.

Nobuyuki Nishizawa, Yukio Okano, Yuji Chatani, +5

Cell Regulation

ImmunologyCell ProliferationCell GrowthPertussis ToxinCellular Physiology +17

Hepatocyte growth factor rapidly induces the tyrosine phosphorylation of 41-kDa and 43-kDa proteins in mouse keratinocytes

Yuji Chatani, Akio Itoh, Tanaka Eiko, +3

Biochemical and Biophysical Research Communications

Tyrosine PhosphorylationHepatocyte Growth FactorDevelopmental BiologySignal TransductionSignaling Pathway +13