The Molecular Basis of ABA-Independent Inhibition of PP2Cs by a Subclass of PYL Proteins

Qi Hao, Ping Yin, Wenqi Li, +6

Molecular Cell

Protein FunctionSignal TransductionMolecular PhysiologyBiochemistryMolecular Pathway +12

Identification and structure–activity relationships of substituted pyridones as inhibitors of Pim-1 kinase

I. Wayne Cheney, Shunqi Yan, T.C. Appleby, +6

Bioorganic & Medicinal Chemistry Letters

Substituted PyridonesMolecular PharmacologyMedicinal ChemistryPim-1 KinaseBiochemistry +13

Kupffer cells are associated with apoptosis, inflammation and fibrotic effects in hepatic fibrosis in rats

Cheng Liu, Qing Tao, Mingyu Sun, +7

Laboratory Investigation

ApoptosisImmunologyPathologyCell DeathHepatic Fibrosis +17

Structure–activity relationship (SAR) studies of quinoxalines as novel HCV NS5B RNA-dependent RNA polymerase inhibitors

Frank Rong, Suetying Chow, Shunqi Yan, +3

Bioorganic & Medicinal Chemistry Letters

Structure–activity RelationshipViral Polymerase StructureMedicineAntiviral Drug DevelopmentAntiviral Therapy +6

Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2

Luigi Carlessi, Giacomo Buscemi, Gary Larson, +3

Molecular Cancer Therapeutics

Discovery of Ziresovir as a Potent, Selective, and Orally Bioavailable Respiratory Syncytial Virus Fusion Protein Inhibitor

Xiufang Zheng, Lu Gao, Lisha Wang, +14

Journal of Medicinal Chemistry

Design, Synthesis, and Antiviral Activity of Adenosine 5‘-Phosphonate Analogues as Chain Terminators against Hepatitis C Virus

Yung‐hyo Koh, Jae Hoon Shim, Jim Zhen Wu, +3

Journal of Medicinal Chemistry

Bioorganic ChemistryHepatitis C VirusAdenosine 5'-Phosphonate AnaloguesAntiviral DrugChemical Biology +15

Design and Synthesis of Orally Bioavailable 4-Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors

Zongxing Qiu, Xianfeng Lin, Mingwei Zhou, +27

Journal of Medicinal Chemistry

Capsid ProteinAntiviral DrugHepatitis B VirusViral Structural ProteinMedicinal Chemistry +15

Syntheses and antitumor activities of N′1,N′3-dialkyl-N′1,N′3-di-(alkylcarbonothioyl) malonohydrazide: The discovery of elesclomol

Shoujun Chen, Lijun Sun, Keizo Koya, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryEnantioselective SynthesisBioorganic ChemistryBiochemistryNatural Sciences +6

Identification and Characterization of Multiple TRIM Proteins That Inhibit Hepatitis B Virus Transcription

Shijian Zhang, Ju‐Tao Guo, Jim Zhen Wu, +1

PLoS ONE

Viral ReplicationTripartite MotifImmunologyHepatitis BMolecular Biology +15