Concepedia

PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms

Daniel J. Freeman, Andrew G. Li, Gang Wei, Heng-Hong Li, Nathalie Kertesz, Ralf Lesche, Andrew Whale, Hilda Martinez-Diaz, Nora Rozengurt, Robert D. Cardiff,

Cancer Cell · 2003 · 515 citations · 47 references

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47

<i>PTEN</i> , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

Jing Li, Clifford Yen, Danny Liaw et al. · Science · 1997 · 4.8K citations

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The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

Tomohiko Maehama, Jack E. Dixon · Journal of Biological Chemistry · 1998 · 3.1K citations · Full text

, , +17

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

Peter A. Steck, Mark A. Pershouse, Samar A. Jasser et al. · Nature Genetics · 1997 · 2.8K citations

, , +11

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

Vuk Stambolic, Akira Suzuki, José Luís de la Pompa et al. · Cell · 1998 · 2.6K citations · Full text

, , +16

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

Danny Liaw, Jing Li, Patricia L. M. Dahia et al. · Nature Genetics · 1997 · 2.1K citations

, , +16