PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms

Daniel J. Freeman, Andrew G. Li, Gang Wei, +9

Cancer Cell

Tumor BiologySignal TransductionSignaling PathwayCell RegulationMedicine +9

PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion

Claire M. Wells, Andrew Whale, Maddy Parsons, +2

Journal of Cell Science

Focal AdhesionsUrologySignal TransductionSignaling PathwayFocal-adhesion Dynamics +13

Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen

Andrew J. Poole, V. Karuppiah, Annabelle Hartt, +22

Nature Communications

PAK4 kinase activity and somatic mutation promote carcinoma cell motility and influence inhibitor sensitivity

Andrew Whale, Anna Dart, Mark Holt, +2

Oncogene

Cancer ResearchSomatic VariantMedicineReceptor Tyrosine KinaseInfluence Inhibitor Sensitivity +8

Distribution of <i>tccP</i> in Clinical Enterohemorrhagic and Enteropathogenic <i>Escherichia coli</i> Isolates

Junkal Garmendia, Zhihong Ren, Sharon M. Tennant, +13

Journal of Clinical Microbiology

TccP2 of O157:H7 and Non-O157 Enterohemorrhagic <i>Escherichia coli</i> (EHEC): Challenging the Dogma of EHEC-Induced Actin Polymerization

Yoshitoshi Ogura, Tadasuke Ooka, Andrew Whale, +14

Infection and Immunity

Functional characterization of a novel somatic oncogenic mutation of PIK3CB

Andrew Whale, Lucy Colman, Letitia Lensun, +2

Signal Transduction and Targeted Therapy

PAK4 interacts with p85 alpha: implications for pancreatic cancer cell migration

Helen King, Kiruthikah Thillai, Andrew Whale, +4

Scientific Reports

Enteropathogenic <i>Escherichia coli</i> O125:H6 Triggers Attaching and Effacing Lesions on Human Intestinal Biopsy Specimens Independently of Nck and TccP/TccP2

Li Bai, Stephanie Schüller, Andrew Whale, +11

Infection and Immunity

Protein SecretionCell AdhesionPathologyEffacing LesionsCytoskeleton +14

TccP2-mediated subversion of actin dynamics by EPEC 2 – a distinct evolutionary lineage of enteropathogenic Escherichia coli

Andrew Whale, Rodrigo T. Hernandes, Tadasuke Ooka, +11

Microbiology

Protein SecretionVirulence FactorPathogenesisMolecular BiologyGut Mucosa +13