Concepedia

Pten Inactivation

PTEN Inactivation is a molecular alteration in which the tumor suppressor gene PTEN undergoes genetic or epigenetic disruption, leading to loss of its phosphatase activity and subsequent dysregulation of the PI3K/AKT signaling pathway in cellular growth and survival.

4.7K

Publications

391.6K

Citations

29.7K

Authors

4K

Institutions

Publications per year

2017–2026

1.5K

Parents

Publications

4.7K

<i>PTEN</i> , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

Jing Li, Clifford Yen, Danny Liaw et al. · Science · 1997 · 4.8K citations

, , +16

Comprehensive molecular characterization of clear cell renal cell carcinoma

Nature · 2013 · 3.5K citations · Full text

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The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

Tomohiko Maehama, Jack E. Dixon · Journal of Biological Chemistry · 1998 · 3.1K citations · Full text

, , +17

MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular Cancer

Fanyin Meng, Roger Henson, Hania Wehbe–Janek et al. · Gastroenterology · 2007 · 2.8K citations · Full text

, , +14

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

Vuk Stambolic, Akira Suzuki, José Luís de la Pompa et al. · Cell · 1998 · 2.6K citations · Full text

, , +16

1–5 of 4.7K

Authors

29.7K

  1. CE
    Charis Eng

    Cleveland Clinic, United States

    110 publications · 14K citations

    63

    h-index

  2. HW
    Hong Wu

    University of California, Los Angeles, United States

    58 publications · 13.3K citations

    49

    h-index

  3. PP
    Pier Paolo Pandolfi

    Beth Israel Deaconess Medical Center, United States

    66 publications · 19.6K citations

    48

    h-index

  4. RP
    Ramon Parsons

    Columbia University, United States

    50 publications · 16.9K citations

    42

    h-index

  5. GB
    Gordon B. Mills

    The University of Texas MD Anderson Cancer Center, United States

    33 publications · 5.7K citations

    28

    h-index

1–5 of 29.7K

Institutions

4K

  1. Harvard University

    Cambridge, United States

    82 h-index

    718 publications

    148.3K citations

  2. The University of Texas MD Anderson Cancer Center

    Houston, United States

    78 h-index

    1.2K publications

    313.8K citations

  3. Cancer Genetics (United States)

    Rutherford, United States

    71 h-index

    471 publications

    112K citations

  4. Memorial Sloan Kettering Cancer Center

    New York, United States

    70 h-index

    642 publications

    235.3K citations

  5. Dana-Farber Cancer Institute

    Boston, United States

    70 h-index

    580 publications

    131K citations

  6. University of California, Los Angeles

    Los Angeles, United States

    62 h-index

    404 publications

    78.6K citations

  7. Johns Hopkins University

    Baltimore, United States

    55 h-index

    515 publications

    77.2K citations

  8. Beth Israel Deaconess Medical Center

    Boston, United States

    53 h-index

    304 publications

    64.4K citations

1–8 of 4K

Venues

  1. Cancer Research

    171 publications · 23.8K citations

    83

    h-index

  2. Oncogene

    131 publications · 12.5K citations

    70

    h-index

  3. PubMed

    Repository · 194 publications · 21.5K citations

    69

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 92 publications · 18.3K citations

    66

    h-index

  5. Clinical Cancer Research

    79 publications · 9.2K citations

    54

    h-index

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