The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

Tomohiko Maehama, Jack E. Dixon

Journal of Biological Chemistry

Crystal Structure of the PTEN Tumor Suppressor

Jie‐Oh Lee, Haijuan Yang, Maria-Magdalena Georgescu, +6

Cell

Crystal StructureMolecular BiologyStructural BiologyTumor SuppressorMedicine +3

Use of double-stranded RNA interference in <i>Drosophila</i> cell lines to dissect signal transduction pathways

James C. Clemens, Carolyn A. Worby, Nancy Simonson-Leff, +4

Proceedings of the National Academy of Sciences

Signal Transduction PathwaysEngineeringGeneticsMolecular GeneticsInsulin Signaling +15

A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1

Osman Nidai Özeş, Hakan Akça, Lindsey D. Mayo, +4

Proceedings of the National Academy of Sciences

Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate

Gregory S. Taylor, Tomohiko Maehama, Jack E. Dixon

Proceedings of the National Academy of Sciences

Heterodimeric Phosphoinositide 3-Kinase Consisting of p85 and p110β Is Synergistically Activated by the βγ Subunits of G Proteins and Phosphotyrosyl Peptide

Hiroshi Kurosu, Tomohiko Maehama, Taro Okada, +6

Journal of Biological Chemistry

Molecular BiologyRelated SubunitsInsulin SignalingSignaling PathwayReceptor Tyrosine Kinase +19

Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11

Masato Sasaki, Kohichi Kawahara, Miki Nishio, +20

Nature Medicine

Mdm2-p53 PathwayTumor BiologyCell RegulationNucleolar Rpl11Medicine +6

Regulation of PTEN Phosphorylation and Stability by a Tumor Suppressor Candidate Protein

Fumiaki Okahara, Hideki Ikawa, Yasunori Kanaho, +1

Journal of Biological Chemistry

Signal TransductionPten FunctionCell RegulationMolecular RegulationMedicine +13

A Sensitive Assay for Phosphoinositide Phosphatases

Tomohiko Maehama, Gregory S. Taylor, James T. Slama, +1

Analytical Biochemistry

Signal TransductionCellular EnzymologyBiochemistryNatural SciencesBioanalysis +4

YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma

Hirofumi Omori, Miki Nishio, Muneyuki Masuda, +15

Science Advances