Orally bioavailable dual MMP-1/MMP-14 sparing, MMP-13 selective α-sulfone hydroxamates

Molecular Properties That Influence the Oral Bioavailability of Drug Candidates

Daniel F. Veber, Stephen R. Johnson, Hung‐Yuan Cheng et al. · Journal of Medicinal Chemistry · 2002 · 8.1K citations

Pharmacy, Pharmacokinetics, Pharmacology +15

In situ zymographic localisation of type II collagen degrading activity in osteoarthritic human articular cartilage

Anthony J. Freemont, Richard Byers, Yetunde O. Taiwo et al. · Annals of the Rheumatic Diseases · 1999 · 68 citations · Full text

Medicine, Pathobiology, Pathology +17

Synthesis and Structure−Activity Relationships of β- and α-Piperidine Sulfone Hydroxamic Acid Matrix Metalloproteinase Inhibitors with Oral Antitumor Efficacy

Daniel P. Becker, Clara I. Villamil, Thomas E. Barta et al. · Journal of Medicinal Chemistry · 2005 · 65 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Coupling of Arylboronic Acids with a Partially Reduced Pyridine Derivative

David J. Wustrow, Lawrence D. Wise · Synthesis · 1991 · 42 citations

Natural Sciences, Chemistry, Catalysis +5

Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si3.gif" overflow="scroll"><mml:mrow><mml:msubsup><mml:mrow><mml:mtext>P</mml:mtext></mml:mrow><mml:mrow><mml:mn>1</mml:mn></mml:mrow><mml:mrow><mml:mo>′</mml:mo></mml:mrow></mml:msubsup></mml:mrow></mml:math> permutations

David Burns, Chunhong He, Yanlong Li et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 17 citations · Full text

Pharmacy, Chemical Biology, Medicinal Chemistry +11