Grace E. Munie

Solution structure and backbone dynamics of the catalytic domain of matrix metalloproteinase-2 complexed with a hydroxamic acid inhibitor

Yiqing Feng, John J. Likos, Leiming Zhu et al. · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · 2002 · 100 citations

Protein Chemistry, Catalytic Domain, Hydroxamic Acid Inhibitor +9

Orally Active MMP-1 Sparing α-Tetrahydropyranyl and α-Piperidinyl Sulfone Matrix Metalloproteinase (MMP) Inhibitors with Efficacy in Cancer, Arthritis, and Cardiovascular Disease

Daniel P. Becker, Thomas E. Barta, Louis J. Bedell et al. · Journal of Medicinal Chemistry · 2010 · 97 citations · Full text

Spare Mmp-1, Pharmacotherapy, Pharmaceutical Chemistry +17

ADAMTS-4 (aggrecanase-1): N-Terminal activation mechanisms

Micky D. Tortorella, Elizabeth C. Arner, Robert L. Hills et al. · Archives of Biochemistry and Biophysics · 2005 · 69 citations

Signal Transduction, Molecular Regulation, N-terminal Activation Mechanisms +3

Synthesis and Structure−Activity Relationships of β- and α-Piperidine Sulfone Hydroxamic Acid Matrix Metalloproteinase Inhibitors with Oral Antitumor Efficacy

Daniel P. Becker, Clara I. Villamil, Thomas E. Barta et al. · Journal of Medicinal Chemistry · 2005 · 64 citations · Full text

Pharmaceutical Science, Breast Oncology, Immunology +23

Structural and Inhibition Analysis Reveals the Mechanism of Selectivity of a Series of Aggrecanase Inhibitors

Micky D. Tortorella, Alfredo G. Tomasselli, Karl J. Mathis et al. · Journal of Biological Chemistry · 2009 · 63 citations · Full text

Aggrecanase Inhibitors, Bioorganic Chemistry, Glycobiology +19