Orally Active MMP-1 Sparing α-Tetrahydropyranyl and α-Piperidinyl Sulfone Matrix Metalloproteinase (MMP) Inhibitors with Efficacy in Cancer, Arthritis, and Cardiovascular Disease

Daniel P. Becker, Thomas E. Barta, Louis J. Bedell, +24

Journal of Medicinal Chemistry

Spare Mmp-1PharmacotherapyPharmaceutical ChemistryInflammatory ArthritisTumor Biology +15

SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype

Daniel L. Flynn, Daniel L. Zabrowski, Daniel P. Becker, +5

Journal of Medicinal Chemistry

LOPHTOR: a convenient flow-based photochemical reactor

Anil Vasudevan, Clara I. Villamil, Jonathan D. Trumbull, +4

Tetrahedron Letters

Chemical EngineeringFlow ChemistryEngineeringPhotochemistryPhotocatalysis +2

Synthesis and Structure−Activity Relationships of β- and α-Piperidine Sulfone Hydroxamic Acid Matrix Metalloproteinase Inhibitors with Oral Antitumor Efficacy

Daniel P. Becker, Clara I. Villamil, Thomas E. Barta, +15

Journal of Medicinal Chemistry

Pharmaceutical ScienceBreast OncologyImmunologyPharmacotherapyPharmaceutical Chemistry +21

Pyrrolizidine Esters and Amides as 5-HT₄ Receptor Agonists and Antagonists

Daniel P. Becker, Daniel L. Flynn, Alan E. Moormann, +6

Journal of Medicinal Chemistry

α-Amino-β-sulphone hydroxamates as potent MMP-13 inhibitors that spare MMP-1

Daniel P. Becker, Thomas E. Barta, Louis J. Bedell, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePotent Mmp-13 InhibitorsPharmacotherapyAnti-cancer Agent +4

Synthesis of Diazepinones via Intramolecular Transamidation

Anil Vasudevan, Clara I. Villamil, Stevan W. Djurić

Organic Letters

Enantioselective SynthesisEngineeringOrganic ChemistryIntramolecular TransamidationChemistry +8

Synthesis and activity of selective MMP inhibitors with an aryl backbone

Thomas E. Barta, Daniel P. Becker, Louis J. Bedell, +8

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistrySelective Mmp InhibitorsBiochemistryAryl BackboneMedicine +6

Selective, orally active MMP inhibitors with an aryl backbone

Thomas E. Barta, Daniel P. Becker, Louis J. Bedell, +5

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryAryl BackboneMedicinePharmacotherapyAnti-cancer Agent +4

(Acyloxy)benzophenones and (acyloxy)-4-pyrones. A new class of inhibitors of human neutrophil elastase

Masateru Miyano, James R. Deason, Akira Nakao, +4

Journal of Medicinal Chemistry

Bioorganic ChemistryChemical BiologyEnzymatic ModificationRedox BiologyPharmaceutical Chemistry +16