Thomas E. Barta

Discovery of Novel 2-Aminobenzamide Inhibitors of Heat Shock Protein 90 as Potent, Selective and Orally Active Antitumor Agents

Kenneth H. Huang, James M. Veal, R. Patrick Fadden et al. · Journal of Medicinal Chemistry · 2009 · 188 citations · Full text

Drug Target, Pharmacotherapy, Chemical Biology +16

Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis

John W. Rice, James M. Veal, R. Patrick Fadden et al. · Arthritis & Rheumatism · 2008 · 134 citations

Orally Active MMP-1 Sparing α-Tetrahydropyranyl and α-Piperidinyl Sulfone Matrix Metalloproteinase (MMP) Inhibitors with Efficacy in Cancer, Arthritis, and Cardiovascular Disease

Daniel P. Becker, Thomas E. Barta, Louis J. Bedell et al. · Journal of Medicinal Chemistry · 2010 · 97 citations · Full text

Spare Mmp-1, Pharmacotherapy, Pharmaceutical Chemistry +17

Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90

Thomas E. Barta, James M. Veal, John W. Rice et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 89 citations

Combinatorial Chemistry, Medicinal Chemistry, Drug Target +10

Application of Chemoproteomics to Drug Discovery: Identification of a Clinical Candidate Targeting Hsp90

Patrick Fadden, Kenneth H. Huang, James M. Veal et al. · Chemistry & Biology · 2010 · 87 citations

Drug Target, Medicine, Natural Sciences +8