SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK

Yutaka Okawa, Teru Hideshima, Paul M. Steed, +12

Blood

Discovery of Novel 2-Aminobenzamide Inhibitors of Heat Shock Protein 90 as Potent, Selective and Orally Active Antitumor Agents

Kenneth H. Huang, James M. Veal, R. Patrick Fadden, +29

Journal of Medicinal Chemistry

Drug TargetPharmacotherapyChemical BiologyNovel 2-Aminobenzamide InhibitorsMedicinal Chemistry +14

Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis

John W. Rice, James M. Veal, R. Patrick Fadden, +9

Arthritis & Rheumatism

Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90

Thomas E. Barta, James M. Veal, John W. Rice, +11

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryDrug TargetBiochemistryNatural Sciences +8

Application of Chemoproteomics to Drug Discovery: Identification of a Clinical Candidate Targeting Hsp90

Patrick Fadden, Kenneth H. Huang, James M. Veal, +26

Chemistry & Biology

Drug TargetMedicineNatural SciencesProteomicsBiomarker Target +6

The Use of High-Content Screening for the Discovery and Characterization of Compounds That Modulate Mitotic Index and Cell Cycle Progression by Differing Mechanisms of Action

Amy F. Barabasz, Briana Foley, James Otto, +2

Assay and Drug Development Technologies

Targeting of Multiple Signaling Pathways by the Hsp90 Inhibitor SNX-2112 in EGFR Resistance Models as a Single Agent or in Combination With Erlotinib

John W. Rice, James M. Veal, Amy F. Barabasz, +6

Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics

Chemoprevention StrategyProlonged Animal SurvivalTumor BiologyHsp90 Inhibitor Snx-2112Signaling Pathway +16

Novel carbazole and acyl-indole antimitotics

Thomas E. Barta, Amy F. Barabasz, Briana Foley, +7

Bioorganic & Medicinal Chemistry Letters

Novel CarbazoleMedicinal ChemistryAntibacterial AgentAntimicrobial CompoundPharmacology +2

Inhibiting Effect of Dehydroascorbic Acid on Cell Division in Ascites Tumors in Mice

Eymard Poydock, D. Reikert, John W. Rice, +1

Pathobiology

Chemoprevention StrategyPathologyCancer BiologyTumor BiologyOxidative Stress +15

Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90

Kenneth H. Huang, Thomas E. Barta, John W. Rice, +14

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryBiochemistryHeat ShockMedicine +6