John W. Rice

SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK

Yutaka Okawa, Teru Hideshima, Paul M. Steed et al. · Blood · 2008 · 208 citations · Full text

Discovery of Novel 2-Aminobenzamide Inhibitors of Heat Shock Protein 90 as Potent, Selective and Orally Active Antitumor Agents

Kenneth H. Huang, James M. Veal, R. Patrick Fadden et al. · Journal of Medicinal Chemistry · 2009 · 188 citations · Full text

Drug Target, Pharmacotherapy, Chemical Biology +16

Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis

John W. Rice, James M. Veal, R. Patrick Fadden et al. · Arthritis & Rheumatism · 2008 · 134 citations

Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90

Thomas E. Barta, James M. Veal, John W. Rice et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 89 citations

Combinatorial Chemistry, Medicinal Chemistry, Drug Target +10

Application of Chemoproteomics to Drug Discovery: Identification of a Clinical Candidate Targeting Hsp90

Patrick Fadden, Kenneth H. Huang, James M. Veal et al. · Chemistry & Biology · 2010 · 87 citations

Drug Target, Medicine, Natural Sciences +8