Jeffery N. Carroll

Orally Active MMP-1 Sparing α-Tetrahydropyranyl and α-Piperidinyl Sulfone Matrix Metalloproteinase (MMP) Inhibitors with Efficacy in Cancer, Arthritis, and Cardiovascular Disease

Daniel P. Becker, Thomas E. Barta, Louis J. Bedell et al. · Journal of Medicinal Chemistry · 2010 · 100 citations · Full text

Medicine, Oncology, Pharmacology +8

High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2)

Huey‐Sheng Shieh, Karl J. Mathis, Jennifer M. Williams et al. · Journal of Biological Chemistry · 2007 · 79 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +6

Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

Mark E. Schnute, Patrick O’Brien, Joe Nahra et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 50 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10

Discovery of<i>N</i>-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2<i>S</i>,5<i>R</i>)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2<i>H</i>-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis

Peter Ruminski, Mark A. Massa, Joseph W. Strohbach et al. · Journal of Medicinal Chemistry · 2015 · 33 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Orally bioavailable dual MMP-1/MMP-14 sparing, MMP-13 selective α-sulfone hydroxamates

Stephen A. Kolodziej, Susan L. Hockerman, Terri L. Boehm et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 22 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +4