Concepedia

Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity

Richard H. Porter, Georg Jaeschke, Will Spooren, Theresa M. Ballard, Bernd Büttelmann, Sabine Kolczewski, Jens‐Uwe Peters, Eric Prinssen, Jürgen Wichmann, Eric Vieira,

Journal of Pharmacology and Experimental Therapeutics · 2005 · 314 citations · 26 references

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Concepts

References

26

Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

N. Kunishima, Yoshimi Shimada, Yuji Tsuji et al. · Nature · 2000 · 1.2K citations

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2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

F. Gasparini, Kurt Lingenhöhl, Natacha Stoehr et al. · Neuropharmacology · 1999 · 720 citations

, , +7

Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain

Carmelo Romano, Michael A. Sesma, Colin T. McDonald et al. · The Journal of Comparative Neurology · 1995 · 673 citations

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Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain

Ryuichi Shigemoto, Sakashi Nomura, Hitoshi Ohishi et al. · Neuroscience Letters · 1993 · 520 citations

, , +14

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine:  A Potent and Highly Selective Metabotropic Glutamate Subtype 5 Receptor Antagonist with Anxiolytic Activity

Nicholas D. P. Cosford, Lida Tehrani, Jeffrey Roppe et al. · Journal of Medicinal Chemistry · 2002 · 400 citations · Full text

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