Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity

Richard H. Porter, Georg Jaeschke, Will Spooren, +11

Journal of Pharmacology and Experimental Therapeutics

Positive allosteric modulators of metabotropic glutamate 1 receptor: Characterization, mechanism of action, and binding site

Frédéric Knoflach, Vincent Mutel, Synèse Jolidon, +5

Proceedings of the National Academy of Sciences

Mglu1 Receptor ResponsesSignal TransductionMolecular PhysiologyBiochemistryG Protein-coupled Receptor +13

Novel Agonists of 5HT_2C Receptors. Synthesis and Biological Evaluation of Substituted 2-(Indol-1-yl)-1-methylethylamines and 2-(Indeno[1,2-<i>b</i>]pyrrol-1-yl)-1-methylethylamines. Improved Therapeutics for Obsessive Compulsive Disorder

Michael Bös, François Jenck, James R. Martin, +4

Journal of Medicinal Chemistry

PsychopharmacologyPharmacotherapySocial SciencesMolecular PharmacologyMedicinal Chemistry +16

9H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers

Eric Vieira, Jörg Huwyler, Synèse Jolidon, +3

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryFunctional SelectivityMedicineNatural Sciences +8

Behavioral Effects of a Synthetic Agonist Selective for Nociceptin/Orphanin FQ Peptide Receptors in Monkeys

Mei‐Chuan Ko, James H. Woods, William E. Fantegrossi, +3

Neuropsychopharmacology

Behavioral NeuroscienceSynthetic Agonist SelectiveMedicineBehavioral PharmacologyFunctional Selectivity +9

Characterization of [³H]‐(2S,2′R,3′R)‐2‐(2′,3′‐dicarboxy‐ cyclopropyl)glycine ([³H]‐DCG IV) binding to metabotropic mGlu₂ receptor‐transfected cell membranes

Jayne Cartmell, Geo Adam, Sylvie Chaboz, +8

British Journal of Pharmacology

Proteinlipid InteractionG-protein-coupled ReceptorCellular PharmacologyCell MembranesExperimental Pharmacology +18

High-Affinity, Non-Peptide Agonists for the ORL1 (Orphanin FQ/Nociceptin) Receptor

Stephan Röver, Geo Adam, Andrea M. Cesura, +5

Journal of Medicinal Chemistry

Drug TargetPain MedicineImmunologyPharmacotherapyPharmaceutical Chemistry +16

Characterization of [3H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using Semliki Forest virus vectors

Christophe Schweitzer, Claudia Kratzeisen, Geo Adam, +7

Neuropharmacology

Signal TransductionMolecular PhysiologyMglu3 ReceptorsMolecular VirologyG Protein-coupled Receptor +9

Structure-activity relationships of substituted 5H-thiazolo[3,2-a]pyrimidines as group 2 metabotropic glutamate receptor antagonists

Jürgen Wichmann, Geo Adam, Sabine Kolczewski, +2

Bioorganic & Medicinal Chemistry Letters

Group 2BiochemistryFunctional SelectivityMedicineMechanism Of Action +5

Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats

François Jenck, Jean‐Luc Moreau, Hemmie H.G. Berendsen, +5

European Neuropsychopharmacology

Molecular PharmacologyAntiaversive EffectsPsychiatryBehavioral NeuroscienceMedicine +9