Jürgen Wichmann

Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity

Richard H. Porter, Georg Jaeschke, Will Spooren et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 314 citations · Full text

Positive allosteric modulators of metabotropic glutamate 1 receptor: Characterization, mechanism of action, and binding site

Frédéric Knoflach, Vincent Mutel, Synèse Jolidon et al. · Proceedings of the National Academy of Sciences · 2001 · 236 citations · Full text

Mglu1 Receptor Responses, Signal Transduction, Molecular Physiology +15

Novel Agonists of 5HT_2C Receptors. Synthesis and Biological Evaluation of Substituted 2-(Indol-1-yl)-1-methylethylamines and 2-(Indeno[1,2-<i>b</i>]pyrrol-1-yl)-1-methylethylamines. Improved Therapeutics for Obsessive Compulsive Disorder

Michael Bös, François Jenck, James R. Martin et al. · Journal of Medicinal Chemistry · 1997 · 97 citations · Full text

Psychopharmacology, Pharmacotherapy, Social Sciences +18

9H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers

Eric Vieira, Jörg Huwyler, Synèse Jolidon et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 96 citations

Medicinal Chemistry, Biochemistry, Functional Selectivity +10

Behavioral Effects of a Synthetic Agonist Selective for Nociceptin/Orphanin FQ Peptide Receptors in Monkeys

Mei‐Chuan Ko, James H. Woods, William E. Fantegrossi et al. · Neuropsychopharmacology · 2009 · 94 citations · Full text

Behavioral Neuroscience, Synthetic Agonist Selective, Medicine +11