An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus

Daniel Lamarre, Paul C. Anderson, Murray D. Bailey, +25

Nature

Antiviral EffectsHepatologyHepatitis C VirusViral HepatitisNs3 Protease Inhibitor +7

5-HT2C Receptor Agonists: Pharmacological Characteristics and Therapeutic Potential

Joel R. Martin, Michael Bös, F. Jenck, +10

Journal of Pharmacology and Experimental Therapeutics

Influence of the 5-HT₆Receptor on Acetylcholine Release in the Cortex:  Pharmacological Characterization of 4-(2-Bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a Potent and Selective 5-HT₆Receptor Antagonist

Claus Riemer, Edilio Borroni, Bernard Levet‐Trafit, +4

Journal of Medicinal Chemistry

Pharmacological CharacterizationSynaptic TransmissionNeurotransmitterReceptor AntagonistPharmacotherapy +18

Characterization of Ro 04‐6790 and Ro 63‐0563: potent and selective antagonists at human and rat 5‐HT₆ receptors

Andrew J. Sleight, Frank Boess, Michael Bös, +3

British Journal of Pharmacology

PharmacotherapyExperimental PharmacologyMolecular PharmacologyPharmacological StudySelective Antagonists +14

Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1

Lee D. Fader, Éric Malenfant, Mathieu Parisien, +32

ACS Medicinal Chemistry Letters

Hiv-1 IntegraseImmunologyMolecular BiologyPharmacotherapyBi 224436 +14

5HT2C receptor agonists exhibit antidepressant-like properties in the anhedonia model of depression in rats

Jean‐Luc Moreau, Michael Bös, F. Jenck, +3

European Neuropsychopharmacology

PsychiatryMood SymptomMedicinePsychotropic MedicationDepression +11

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly

Lee D. Fader, Richard C. Bethell, Pierre Bonneau, +22

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryHeterocyclicBiochemistryNatural Sciences +6

Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives

Pierre L. Beaulieu, Michael Bös, Yves Bousquet, +11

Bioorganic & Medicinal Chemistry Letters

Benzimidazole DerivativesPreliminary SarMedicineNon-nucleoside InhibitorsAntiviral Drug Development +7

Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor

Craig Fenwick, Ma’an Amad, Murray D. Bailey, +24

Antimicrobial Agents and Chemotherapy

Novel Agonists of 5HT_2C Receptors. Synthesis and Biological Evaluation of Substituted 2-(Indol-1-yl)-1-methylethylamines and 2-(Indeno[1,2-<i>b</i>]pyrrol-1-yl)-1-methylethylamines. Improved Therapeutics for Obsessive Compulsive Disorder

Michael Bös, François Jenck, James R. Martin, +4

Journal of Medicinal Chemistry

PsychopharmacologyPharmacotherapySocial SciencesMolecular PharmacologyMedicinal Chemistry +16