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Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists

Henrietta Dehmlow, Rubén Alvarez Sánchez, Stephan Bachmann, Caterina Bissantz, Fritz Bliss, Karin Conde‐Knape, Martin Graf, Rainer E. Martin, Ulrike Obst Sander, S. Raab,

Bioorganic & Medicinal Chemistry Letters · 2013 · 16 citations · 23 references

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23

Lead- and drug-like compounds: the rule-of-five revolution

Christopher A. Lipinski · Drug Discovery Today Technologies · 2004 · 6.1K citations

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TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

Charles Thomas, Antimo Gioiello, Lilia G. Noriega et al. · Cell Metabolism · 2009 · 1.8K citations · Full text

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N-methoxy-n-methylamides as effective acylating agents

Steven Nahm, Steven M. Weinreb · Tetrahedron Letters · 1981 · 1.8K citations

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Identification of membrane-type receptor for bile acids (M-BAR)

Takaharu Maruyama, Yasuhisa Miyamoto, Takao Nakamura et al. · Biochemical and Biophysical Research Communications · 2002 · 975 citations

, , +14

Expanding Pd-Catalyzed C−N Bond-Forming Processes:  The First Amidation of Aryl Sulfonates, Aqueous Amination, and Complementarity with Cu-Catalyzed Reactions

Xiaohua Huang, Kevin W. Anderson, Danilo Zim et al. · Journal of the American Chemical Society · 2003 · 767 citations

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