Concepedia

1-(3′,4′-Dichloro-2-fluoro[1,1′-biphenyl]-4-yl)-cyclopropanecarboxylic Acid (CHF5074), a Novel γ-Secretase Modulator, Reduces Brain β-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer’s Disease without Causing Peripheral Toxicity

Bruno P. Imbimbo, Elda Del Giudice, Davide Colavito, Antonello D’Arrigo, Maurizio Dalle Carbonare, Gino Villetti, Fabrizio Facchinetti, Roberta Volta, Vladimiro Pietrini, M. F. Baroc,

Journal of Pharmacology and Experimental Therapeutics · 2007 · 85 citations · 40 references

DOI

Concepts

References

40

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

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Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

Johan H. van Es, Mariëlle van Gijn, Orbicia Riccio et al. · Nature · 2005 · 1.5K citations · Full text

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A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity

Sascha Weggen, Jason L. Eriksen, Pritam Das et al. · Nature · 2001 · 1.4K citations

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Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease

Takeshi Kawarabayashi, Linda H. Younkin, Takaomi C. Saido et al. · Journal of Neuroscience · 2001 · 1.1K citations · Full text

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Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss

Yuesong Gong, Lei Chang, Kirsten L. Viola et al. · Proceedings of the National Academy of Sciences · 2003 · 1.1K citations · Full text

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