Roberta Volta

CHF5074, a novel γ‐secretase modulator, attenuates brain β‐amyloid pathology and learning deficit in a mouse model of Alzheimer's disease

Birgit Hutter‐Paier, Gino Villetti, Fabrizio Facchinetti et al. · British Journal of Pharmacology · 2009 · 85 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

1-(3′,4′-Dichloro-2-fluoro[1,1′-biphenyl]-4-yl)-cyclopropanecarboxylic Acid (CHF5074), a Novel γ-Secretase Modulator, Reduces Brain β-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer’s Disease without Causing Peripheral Toxicity

Bruno P. Imbimbo, Elda Del Giudice, Davide Colavito et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 85 citations

Life Sciences, Neuroscience, Pharmacology +17

CHF6001 II: A Novel Phosphodiesterase 4 Inhibitor, Suitable for Topical Pulmonary Administration—In Vivo Preclinical Pharmacology Profile Defines a Potent Anti-Inflammatory Compound with a Wide Therapeutic Window

Gino Villetti, Chiara Carnini, Loredana Battipaglia et al. · Journal of Pharmacology and Experimental Therapeutics · 2015 · 51 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +15

Novel Class of Benzoic Acid Ester Derivatives as Potent PDE4 Inhibitors for Inhaled Administration in the Treatment of Respiratory Diseases

Elisabetta Armani, Gabriele Amari, Andrea Rizzi et al. · Journal of Medicinal Chemistry · 2014 · 47 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

In vitro and in vivo profiling of CHF5022 and CHF5074

Bruno P. Imbimbo, Elda Del Giudice, Valentina Cenacchi et al. · Pharmacological Research · 2007 · 43 citations

Medicine, Pharmacology, Experimental Pathology +3