In vitro and in vivo profiling of CHF5022 and CHF5074

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Karen Hsiao, Paul F. Chapman, Steven P. Nilsen et al. · Science · 1996 · 4.2K citations

Life Sciences, Neurobiology, Neuroscience +17

A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity

Sascha Weggen, Jason L. Eriksen, Pritam Das et al. · Nature · 2001 · 1.4K citations

Life Sciences, Neuroscience, Pharmacology +14

Ibuprofen Suppresses Plaque Pathology and Inflammation in a Mouse Model for Alzheimer's Disease

Giselle P. Lim, Fu Yang, Tinyi Chu et al. · Journal of Neuroscience · 2000 · 880 citations · Full text

Medicine, Neuroscience, Pharmacology +17

NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo

Jason L. Eriksen, Sarah A. Sagi, Tawnya E. Smith et al. · Journal of Clinical Investigation · 2003 · 620 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +17

Modulation of Notch Processing by γ-Secretase Inhibitors Causes Intestinal Goblet Cell Metaplasia and Induction of Genes Known to Specify Gut Secretory Lineage Differentiation

Joseph Milano, Jenny McKay, Claude Dagenais et al. · Toxicological Sciences · 2004 · 565 citations

Medicine, Medicinal Chemistry, Pharmacology +15