CHF5074, a novel γ‐secretase modulator, attenuates brain β‐amyloid pathology and learning deficit in a mouse model of Alzheimer's disease - Concepedia

Concepedia

Publication | Open Access

CHF5074, a novel γ‐secretase modulator, attenuates brain β‐amyloid pathology and learning deficit in a mouse model of Alzheimer's disease

DOI Full Paper Access

85

Citations

33

References

2009

Year

Birgit Hutter‐Paier, Gino Villetti, Fabrizio Facchinetti, Valentina Cenacchi, Roberta Volta, Annamaria Lanzillotta, Marina Pizzi, Manfred Windisch

British Journal of Pharmacology

Abstract

Chronic CHF5074 treatment reduced brain beta-amyloid burden, associated microglia inflammation and attenuated spatial memory deficit in hAPP mice. This novel gamma-secretase modulator is a promising therapeutic agent for Alzheimer's disease.

References

	Year	Citations

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