NF‐κB p50/RelA and c‐Rel‐containing dimers: opposite regulators of neuron vulnerability to ischaemia

Ilenia Sarnico, Annamaria Lanzillotta, F. Boroni, +7

Journal of Neurochemistry

ApoptosisImmunologyCell DeathDifferent DimersSynaptic Signaling +23

Targeted acetylation of NF-kappaB/RelA and histones by epigenetic drugs reduces post-ischemic brain injury in mice with an extended therapeutic window

Annamaria Lanzillotta, Giuseppe Pignataro, Caterina Branca, +6

Neurobiology of Disease

Post-ischemic Brain InjuryExtended Therapeutic WindowMedicineEpigenetic ChangeCell Death +12

The acetylation of RelA in Lys310 dictates the NF-κB-dependent response in post-ischemic injury

Annamaria Lanzillotta, Ilenia Sarnico, Rosaria Ingrassia, +8

Cell Death and Disease

CHF5074, a novel γ‐secretase modulator, attenuates brain β‐amyloid pathology and learning deficit in a mouse model of Alzheimer's disease

Birgit Hutter‐Paier, Gino Villetti, Fabrizio Facchinetti, +5

British Journal of Pharmacology

The γ-Secretase Modulator CHF5074 Restores Memory and Hippocampal Synaptic Plasticity in Plaque-Free Tg2576 Mice

Claudia Balducci, Bisan Mehdawy, Lydia Mare, +16

Journal of Alzheimer s Disease

Synaptic TransmissionAbnormal Amyloid-βHippocampal Synaptic PlasticitySynaptic SignalingSocial Sciences +21

CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid

Vanessa Porrini, Annamaria Lanzillotta, Caterina Branca, +8

Neuroscience

InflammationNeurodegenerative DiseasesAlzheimer's DiseasePlaque-free Tg2576 MicePrimary Glial Cultures +8

1B/(−)IRE DMT1 Expression during Brain Ischemia Contributes to Cell Death Mediated by NF-κB/RelA Acetylation at Lys310

Rosaria Ingrassia, Annamaria Lanzillotta, Ilenia Sarnico, +8

PLoS ONE

Synergistic Association of Valproate and Resveratrol Reduces Brain Injury in Ischemic Stroke

Lara Faggi, Giuseppe Pignataro, Edoardo Parrella, +11

International Journal of Molecular Sciences

The γ-Secretase Modulator CHF5074 Reduces the Accumulation of Native Hyperphosphorylated Tau in a Transgenic Mouse Model of Alzheimer’s Disease

Annamaria Lanzillotta, Ilenia Sarnico, Marina Benarese, +7

Journal of Molecular Neuroscience

Knockout MouseNeurodegenerative Diseasesγ-Secretase Modulator Chf5074Molecular NeuroscienceAlzheimer's Disease +11

PEA and luteolin synergistically reduce mast cell-mediated toxicity and elicit neuroprotection in cell-based models of brain ischemia

Edoardo Parrella, Vanessa Porrini, Rosa Anna Iorio, +7

Brain Research

Cell-based ModelsMedicineMast Cell DisorderCell DeathNeuropharmacology +11