CHF6001 I: A Novel Highly Potent and Selective Phosphodiesterase 4 Inhibitor with Robust Anti-Inflammatory Activity and Suitable for Topical Pulmonary Administration

Nadia Moretto, Paola Caruso, Raffaella Bosco, +18

Journal of Pharmacology and Experimental Therapeutics

Bis(L-amino acid amidato) copper(II) complexes as chiral eluents in the enantiomeric separation of D,L-dansylamino acids by reversed-phase high-performance liquid chromatography

Elisabetta Armani, Lia Barazzoni, Arnaldo Dossena, +1

Journal of Chromatography A

Chiral EluentsBiochemistryNatural SciencesCoordination ComplexL-dansylamino Acids +9

Novel Class of Benzoic Acid Ester Derivatives as Potent PDE4 Inhibitors for Inhaled Administration in the Treatment of Respiratory Diseases

Elisabetta Armani, Gabriele Amari, Andrea Rizzi, +23

Journal of Medicinal Chemistry

AsthmaPharmaceutical ScienceInflammatory Lung DiseaseLung InflammationPotent Pde4 Inhibitors +17

Enantiomeric separation of D,L-Dns-amino acids by one- and two-dimensional thin-layer chromatography

Rosangela Marchelli, Roberta Virgili, Elisabetta Armani, +1

Journal of Chromatography A

EngineeringBiochemistrySeparation ScienceGas ChromatographyEnantiomeric Separation +8

Functionalized pyrazoles and pyrazolo[3,4-d]pyridazinones: Synthesis and evaluation of their phosphodiesterase 4 inhibitory activity

Pierfrancesco Biagini, Claudio Biancalani, Alessia Graziano, +13

Bioorganic & Medicinal Chemistry

Inhibitory ActivityBiochemistryMedicineNatural SciencesPhosphodiesterase 4 +6

Copper(II) complexes of diamino-diamido-type ligands as chiral eluents in the enantiomeric separation of d,l-dansylamino acids by reversed-phase high-performance liquid chromatography

Elisabetta Armani, Arnaldo Dossena, Rosangela Marchelli, +1

Journal of Chromatography A

Diamino-diamido-type LigandsChiral EluentsBiochemistryNatural SciencesCoordination Complex +6

Discovery of Diaryl Imidazolidin-2-one Derivatives, a Novel Class of Muscarinic M3 Selective Antagonists (Part 1)

Ilaria Peretto, Roberto Forlani, Claudia Fossati, +25

Journal of Medicinal Chemistry

Medicinal ChemistryPart 1BiochemistryFunctional SelectivityMedicine +13

Synthesis, pharmacological evaluation, and structure–activity relationships of benzopyran derivatives with potent SERM activity

Gabriele Amari, Elisabetta Armani, Silvia Ghirardi, +8

Bioorganic & Medicinal Chemistry

Pharmaceutical ScienceDerivative (Chemistry)Benzopyran DerivativesBiochemistryMedicine +7

Reaction of aldehydes and ketones with t-butyl bromide-dimethyl sulphoxide

Elisabetta Armani, Arnaldo Dossena, Rosangela Marchelli, +1

Tetrahedron

T-butyl Bromide-dimethyl SulphoxideOrganic ChemistryChemistryAsymmetric CatalysisEnantioselective Synthesis

Discovery and Optimization of Thiazolidinyl and Pyrrolidinyl Derivatives as Inhaled PDE4 Inhibitors for Respiratory Diseases

Laura Carzaniga, Gabriele Amari, Andrea Rizzi, +22

Journal of Medicinal Chemistry

Pharmaceutical ScienceInflammatory Lung DiseasePhosphodiesterase 4Potent Pde4 InhibitorsInhaled Pde4 Inhibitors +16