Concepedia

Functionalized pyrazoles and pyrazolo[3,4-d]pyridazinones: Synthesis and evaluation of their phosphodiesterase 4 inhibitory activity

Pierfrancesco Biagini, Claudio Biancalani, Alessia Graziano, Nicoletta Cesari, Maria Paola Giovannoni, Agostino Cilibrizzi, Vittorio Dal Piaz, Claudia Vergelli, Letizia Crocetti, Maurizio Delcanale,

Bioorganic & Medicinal Chemistry · 2010 · 28 citations · 18 references

DOIFull text

Open access

Concepts

References

18

Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases

G.L. Card, B.P. England, Yoshihisa Suzuki et al. · Structure · 2004 · 431 citations · Full text

, , +14

A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design

G.L. Card, Landy K. Blasdel, B.P. England et al. · Nature Biotechnology · 2005 · 206 citations · Full text

, , +12

The inhibitory profile of Ibudilast against the human phosphodiesterase enzyme family

Lucien C.D. Gibson, Stuart F. Hastings, Ian McPhee et al. · European Journal of Pharmacology · 2006 · 148 citations

, , +13

Melatonin receptors in brain

Lennard P. Niles, Y. Nancy Wong, Ram K. Mishra et al. · European Journal of Pharmacology · 1979 · 126 citations

, , +12

Stimulation of beta adrenoceptors in a human monocyte cell line (U937) up-regulates cyclic AMP-specific phosphodiesterase activity.

Theodore J. Torphy, Han-liang Zhou, L B Cieslinski · Journal of Pharmacology and Experimental Therapeutics · 1992 · 124 citations

, , +13