Concepedia

Anti-EGFR Antibody Efficiently and Specifically Inhibits Human TSC2−/− Smooth Muscle Cell Proliferation. Possible Treatment Options for TSC and LAM

Elena Lesma, V. Grande, Silvia Ancona, Stephana Carelli, Anna Maria Di Giulio, Alfredo Gorio

PLoS ONE · 2008 · 26 citations · 33 references

DOIFull text

Open access

Abstract

Our results show that an EGF independent pathway is more important than that involving IGF-I for growth and survival of TSC(-/-) ASM cells, and such EGF-dependency is the result of the lack of tuberin.

References

33

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Ken Inoki, Yong Li, Tianquan Zhu et al. · Nature Cell Biology · 2002 · 3K citations

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Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

Vuk Stambolic, Akira Suzuki, José Luís de la Pompa et al. · Cell · 1998 · 2.5K citations · Full text

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Identification and characterization of the tuberous sclerosis gene on chromosome 16

Cell · 1993 · 1.7K citations

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Sirolimus for Angiomyolipoma in Tuberous Sclerosis Complex or Lymphangioleiomyomatosis

John J. Bissler, Francis X. McCormack, Lisa R. Young et al. · New England Journal of Medicine · 2008 · 1.3K citations · Full text

Phosphorylation and Functional Inactivation of TSC2 by Erk

Li Ma, Zhenbang Chen, Hediye Erdjument‐Bromage et al. · Cell · 2005 · 1.3K citations · Full text

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